1. fore

2. of

3. about

4. at

1. in

2. at

3. by

4. on

1. up, in

2. on, in

3. with, in

4. in, with

1. a

2. on

3. the

4. with

1. great attempts but insignificant achievement.

2. to make futile attempts.

3. to end up in failures after great labor.

4. to achieve something valuable after an arduous search.